Dr Mark Buckley による神経科学講義(英語使用) 

2013年4月18日(木) 〜19日(金)

片平キャンパス 生命科学プロジェクト研究棟 1F会議室

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Dr Mark Buckley (University of Oxford)

Behavioural Neuroscience: Learning and Memory systems in the brain

4月18日(木) 10:00~12:00、13:30~15:30
4月19日(金) 10:00~12:00

片平キャンパス 生命科学プロジェクト研究棟 1F会議室



10:00 – 12:00
Lecture 1: Introduction to amnesia and long-term declarative memory:
Part (i): causes of amnesia; consolidation theory; multiple-trace theory, state-dependency theory
Part (ii): medial temporal lobe memory system theory; episodic memory theory

13:30 – 15:30
Lecture 2: What, Where, and When.
Part (i): perceptuo-mnemonic theory; memory for ‘what'; semantic memory
Part (ii): spatial memory; hippocampal function


10:00 – 12:00
Lecture 3: Becoming episodic
Part (i): recollection vs familiarity; autonoetic awareness
Part (ii): Do animals have episodic memory and what can we learn about it from studying them?

These lectures will introduce the audience to the amnesic syndrome, discuss explanations for its occurrence, and then explore the neural underpinning of declarative memory. The causes of the most common types of amnesia will be discussed including Korsakoff’s syndrome and medial temporal lobe amnesia. The lectures will discuss global amnesia wherein anterograde and retrograde amnesia co-occur and also highlight occasions when they dissociate. Importantly, the lectures will also characterize the different categories of memory that theorists speak about, including declarative versus non-declarative memory; episodic versus semantic memory; and domain-specific accounts of memory loss. Influential theories that purport to account for the observed pattern of spared and impaired memory will be introduced, namely consolidation theory, multiple-trace theory, and state-dependency theory, and the relative strengths and weaknesses of each will be discussed. The lectures will proceed to investigate the neural basis of memory systems. In particular, two historically influential theories will be critically evaluated, namely Squire’s Medial Temporal Lobe Memory System theory and Tulving’s Episodic Memory theory. The more recently proposed Perceptuo-Mnemonic theory has gained a lot of traction recently and this theory will also be evaluated in-depth as it presents new data that challenges both of the aforementioned influential theories. The functional role of key regions of the brain that these theories discuss, including the hippocampus and perirhinal cortex in particular will be re-evaluated in light of new data relevant to these theories and the lectures will highlight how and why. The lectures will also esplore the neural basis underlying memory for what, where and when, given the importance that episodic memory theory ascribes to such elements of episodic memory. However, episodic memory considers other aspects of memory that cannot be captured by such domain-specific categories namely recollection versus familiarity and the neural basis of each will be discussed. Finally, one of the most elusive defining elements of episodic memory from the perspective of behavioural neuroscience is autonoetic awareness. The lectures will therefore proceed to discuss to what extent animals can even be said to possess episodic memory. The concept of episodic-like memory will be introduced and other ideas pertaining to this such as metamemory, and what we know about their neural basis from studying animals will be outlined.